Elevated DGP antibodies (and especially DGP-IgG) are often seen in patients with celiac disease on a gluten-containing diet. They appear to have approximately the same value of the tTG-IgA antibody test. However, it appears that in very young children (i.e., in the first two years of life) DGP-IgG do provide a better test for celiac… Read more »
(Updated .)Keyword: dgp
In follow-up blood testing, why would tTG be negative and DGP be positive?
If the slightly positive test is the DGP-IgA, you can disregard this value, as it can be misleading. If the DGP-IgG is positive it probably means you’re ingesting small amounts of gluten, possibly from cross-contamination, which are raising antibodies but not enough to trigger a tTG or a mucosal response. Basically, in either case you… Read more »
(Updated .)What is the percentage of false positives for DGP-IgA?
DGP-IgA is less specific than DGP-IgG and should not be relied upon as a follow-up test for those with celiac disease.
(Updated .)How much exposure to gluten does it take for DGP to become elevated and how long before it will return to normal?
There is no general rule that applies to all, but we learn from each patient. That said, typically DGP are more sensitive to gluten than tTG, so they become elevated before tTG and disappear sooner than tTG once on a gluten-free diet.
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