Keyword: villous atrophy

Does the villous atrophy present differently at the lab or look the same? In other words, with persistent villous atrophy after a gluten-free diet, would the biopsy confirm active celiac disease and/or another cause?

It depends on what the pathologist describes. Villous atrophy is important and well defined, but if in addition the pathologist for instance describes intense neutrophilic infiltration, this would point toward something like Crohn’s, or with eosinophils, this could be eosinophilic enteritis, and so on. In a few words: villous atrophy is only part of the… Read more »

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Is there any connection between mesenteric lymphadenitis and celiac disease?

Mesenteric lymphadenitis. This condition is not seen more frequently in celiac patients than in the general population. If the condition were to occur as a result of celiac disease, the association should not persist once the gluten-free diet has been established for years. However, sometimes enlargement of lymphoid tissue in the terminal ileum can be… Read more »

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Does the villous atrophy present differently at the lab or look the same? In other words, with persistent villous atrophy after a gluten free diet, would the biopsy confirm active celiac disease and/or another cause?

It depends on what the pathologist describes. Villous atrophy is important and well defined, but if in addition the pathologist for instance describes intense neutrophilic infiltration, this would point toward something like Crohn’s, or with eosinophils, this could be eosinophilic enteritis, and so on. In a few words: villous atrophy is only part of the… Read more »

(Updated .)

What else can cause villus atrophy in the small intestine other than celiac disease?

There are many causes for villus atrophy, the most common being immune deficiencies, food allergies and Giardia infections. In addition, Crohn’s disease is known to be often associated with low positive tTG and the changes in the duodenal biopsies can indeed be similar. Causes of Villous Atrophy Other Than Celiac Disease Giardiasis Collagenous sprue Common-variable immunodeficiency… Read more »

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