Keyword: gliadin

If I understand correctly, there isn’t a gluten allergy because celiac is an autoimmune response, while gluten intolerance is a gastrointestinal response. For someone to have a gluten allergy they would have to be allergic to the proteins of glutenin and gliadin and have an allergic response. Is it even possible to have a true allergy to glutenin and gliadin? Obviously I am not an expert but from my research there isn’t a gluten allergy, it is a misused/inaccurate phrase that is used to describe gluten intolerance and non celiac gluten sensitivity.

When we say “wheat allergy” it is clear that there is an allergic response to the ingestion of wheat; and because it is only protein that causes an allergic reaction, one can assume “wheat allergy” is indeed a reaction to the protein content of wheat, hence most likely either glutenins or gliadins (although wheta also… Read more »

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Why do 20% of healthy people make antibodies against gliadin?

Probably because they’ve had a somewhat increased intestinal permeability at a time when they ate gluten, (e.g., during a stomach flu) and the gut immune system has reacted by producing anti-food protein antibodies. Their presence simply indicates that gluten was ingested, and otherwise has no general clinical meaning.

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Which blood tests should I have to screen for celiac disease?

You should have both tTG-IgA and total serum IgA tests to screen for celiac disease. As long as you produce IgA (total serum IgA confirms you do), tTG-IgA is 98% accurate in measuring elevated antibodies. If you are IgA deficient, or if there is some other equivocating factor to potentially compromise the blood test, then… Read more »

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