Answer Bank

Frequently Asked Questions


Will the biopsy continue to be the gold standard for diagnosis?

It’s very likely that the biopsy will remain the gold standard for years to come; approximately 90% of new cases are diagnosed using an endoscopic biopsy as part of the diagnosis. Only in rare cases is a diagnosis made without a biopsy as part of the diagnosis. In these rare cases a patient must have at least one of the genes for celiac disease, tTG and EMA elevated more than 10x normal, and a positive response to a gluten-free diet. Those who should receive a biopsy to diagnose celiac disease include those with:

  • Positive antibody blood test prior to starting a gluten-free diet.
  • Unexplained iron deficiency anemia not responding to therapy.
  • Early osteoporosis.
  • Neuropathy/ataxia.
  December, 2012