Frequently Asked Questions
Is the Anti-Gliadin Antibodies (AGA) test reliable for diagnosing celiac disease?
AGA are anti-food protein antibodies; as such, they are not indicative of any autoimmune reactions. They appear only if the patient has been eating gluten, but–and this is the point–they are not linked to any detectable adverse reaction to gluten. In other words, they can appear in individuals who eat gluten as a response to it touching the gut, but do not necessarily correlate with any clinical expressions.
Thus, patients with true non-celiac gluten sensitivity, patients with IBS and no gluten sensitivity, as well as individuals who are totally healthy (perhaps a bit less commonly, but not significantly so) may all have positive (or negative) AGA.
AGA should not be relied upon to prove or disprove the diagnosis of celiac disease or non-celiac gluten sensitivity. January, 2013