Categorized: About Celiac Disease

Can you have celiac disease without having the genes for it?

This topic raises much debate. The current thought shared by the many physicians and scientists is that 1-2% of celiacs may not possess the celiac-specific genes HLA-DQ2 and/or DQ8. Our Dr. Guandalini and Dr. Bob Anderson, chief scientific officer of ImmusanT, believe the genes are necessary to initiate the immunologic response of celiac disease, hence… Read more »

(Updated .)

Some have suggested the term “gluten-related disorders” instead of “gluten intolerance” as an umbrella term for celiac disease, gluten sensitivity and wheat allergy. What are your thoughts?

Many publications have appeared discussing different definitions; a universal standard is still a work in progress. Until an official agreement is reached, we believe our umbrella term, “gluten intolerance,” is a valid one, as it carries no implications of a specific mechanism for the adverse effects of gluten ingestion. That said, we also agree with… Read more »

(Updated .)

How is it possible for someone to have damaged villi and not have symptoms?

We actually don’t know why some people have damaged villi without symptoms. It’s possibly because the extent of the damaged villi is small and limited to the area of the biopsies, and the rest of the intestine (there are seven yards of it!) is compensating for the damaged area.

(Updated .)