Categorized: About Celiac Disease

Does the villous atrophy present differently at the lab or look the same? In other words, with persistent villous atrophy after a gluten-free diet, would the biopsy confirm active celiac disease and/or another cause?

It depends on what the pathologist describes. Villous atrophy is important and well defined, but if in addition the pathologist for instance describes intense neutrophilic infiltration, this would point toward something like Crohn’s, or with eosinophils, this could be eosinophilic enteritis, and so on. In a few words: villous atrophy is only part of the… Read more »

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Can Accutane trigger celiac disease?

Although there is no clinical data yet to prove that Accutane (or any forms of retinoic acid), which treats severe acne, can trigger celiac disease, it is true that retinoic acid in animal systems–in the context of a mipre-existing even minimal intestinal inflammation–may amplify an inflammatory response. If we put this in context of celiac disease, then… Read more »

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What are some of the symptoms of celiac disease?

Recurring abdominal bloating/pain Chronic diarrhea/constipation Vomiting Liver and biliary tract disorders (transaminitis, fatty liver, primary sclerosing cholangitis, etc.) Weight loss Pale, foul-smelling stool Iron-deficiency anemia that does not respond to iron therapy Fatigue Failure to thrive or short stature Delayed puberty Pain in the joints Tingling numbness in the legs Pale sores inside the mouth… Read more »

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Is the prevalence of celiac disease increasing or decreasing?

The most recent study in the United States showed that 1 in 133, or roughly 1% of the population, have celiac disease. More recent studies in Europe show the prevalence has increased to approximately 2% of the population. Logic tells us that we’re following the same trend as Europe since we share the same genetic… Read more »

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If three things come together to cause celiac disease—over-responsive immune system, genetic predisposition and individual environment—what is meant by individual environment?

“Individual environment” means the combination of factors that combine to create the ideal conditions for celiac disease to develop: modalities of delivery (C-section vs. natural birth), type of bacteria that inhabits one’s gut, early and excessive use of antibiotics, episodes of infections suffered, traumas and possibly other factors yet to be identified.

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What triggers celiac disease?

Doctors acknowledge anecdotally that trauma and other stresses (e.g., illness, pregnancy) can trigger celiac disease, but there is no specific epidemiological research data to support a definitive conclusion.

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