What is non-celiac gluten sensitivity?

Non-celiac gluten sensitivity is an adverse food-induced reaction, possibly immune-mediated, but for which we have no diagnostic test available. This is a reaction in the digestive tract that causes gastrointestinal symptoms similar to irritable bowel syndrome (IBS). It may also lead to other body systems problems, such as fatigue, headache, etc. Unlike celiac disease however, it’s not restricted to people that are HLA-DQ2 and/or DQ8 (the genes that must be present for celiac disease to exist), and it might be transient. Also, there is no known association with autoimmune conditions, and it’s not known to be associated, if untreated, with long-term risk of malignancies.

Although there is currently no diagnostic test (even an intestinal biopsy would be normal), we’re actively involved in research to define a biological marker that could be used to support a diagnosis of non-celiac gluten sensitivity.